Fatty Liver: Relationship between Fatty Liver and Type-2 Diabetes; Important research of IIT Mandi

Fatty Liver And Type 2 Diabetic :  There is a biochemical relationship between fatty liver and type 2 diabetes. This matter has come to light in the research of the researchers of the Indian Institute of Technology (IIT Mandi) in Mandi. The researchers said that this research will be of great help in the treatment of people with non-alcoholic fatty liver disease (NAFLD). 

This research is considered to be very important for India. The number of patients suffering from NAFLD disease is increasing in India. According to a recent research, nearly 40 percent of adults are facing the problem of NAFLD. NAFLD is associated with type-2 diabetes. Almost 50 million adults in India have both these diseases. 

IIT-Mandi’s findings have been published in the journal Diabetes. Assistant Professor of School of Biosciences and Bioengineering at IIT Mandi Dr. Surbhi Dogra, Priya Rawat with Prasenjit Mandal, P. Vineeth Daniel and CSIR-Indian Institute of Chemical Biology Dr. Partha Chakravati, Sujay Maiti, Avishek Paul, Dr. Kaushik Das and Dr. of IPGMER and SSKM Hospital. Sauvik Mitra has written this research paper. 

Dr. NAFLD is an independent predictor of insulin resistance and T2DM, said Prasenjit Mandal. How NAFLD  affects pancreatic β-cells that secrete insulin is not known.                  

The study analyzed blood samples drawn from obese mice and human NAFLD patients. Both samples were found to have high levels of a calcium-binding protein called S100A6. This  protein is released from the fatty liver. This protein acts as a link between the liver and the pancreas. 

S100A6 adversely affects the insulin secretory capacity of β-cells. This increases the incidence of T2DM. At the biochemical level, S100A6 was found to inhibit insulin secretion by activating the  Advanced Glycation End product (RAGE)  receptor on pancreatic beta cells.

Surbhi Dogra of IIT Mandi said the research found that depletion of S100A6 improved insulin secretion and blood glucose regulation in mice. 

The research done by IIT Mandi researchers is said to be important in many ways.   in fatty liver Molecular and cellular processes associated with S100A6 secretion affect β-cell insulin. Elevated levels of S100A6 in the blood can be used to identify the risk of T2DM in NAFLD patients. 

Circulating S100A6 from the blood may allow β-cell function to continue optimally. Furthermore, the biochemical pathway by which S100A6 acts has been revealed. Using RAGE antagonistic molecules can restore β-cell function in NAFLD patients.

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